Bring a large pot of salted water to a boil. Cook the penne according to package directions until al dente. Drain and set aside.
Heat the olive oil in a large skillet over medium high heat. Add the ground beef, salt, pepper, garlic powder, onion powder, and oregano. Cook, breaking the meat apart as it browns. Drain off any excess grease.
Add the Rotel, whole milk, Velveeta cubes, and shredded cheddar. Stir until the cheeses melt and the mixture becomes creamy. Let it come just to a boil, then immediately lower the heat. Simmer for 3 to 4 minutes so the sauce thickens slightly.
Add the cooked pasta to the skillet and toss until everything is coated in the sauce.
Garnish with parsley or cilantro if you like.
Notes
The spice level depends entirely on the Ro-tel you choose. Mild keeps things gentle, which is why you use it for your family. Original has a solid kick. Hot Ro-tel… well, that’s for people who think dinner isn’t complete unless their forehead is glowing.